Some Symptomatic Effects of Addictive Drugs out of Addictive

Amnesia, memory disorders

Anxiety disorder

Delirium

Mood troubles

Psychotics troubles

Sexual disorder

Sleep disorder

opioids

yes

yes

yes

yes

sedative hypnotic (benzo.)

yes

if for too long

yes

yes

yes

yes

inhalant / solvant

yes

yes

yes

yes

yes

amphetamines

yes

yes

yes

yes

yes

yes

caffeine

yes

yes

cocaine/crack

yes

yes

yes

yes

yes

yes

nicotine

yes

yes

yes

hallucignogenous

yes

yes

yes

yes

alcohol

yes

yes

yes

yes

yes

yes

Some adverse secondary effects in common 2nd generation antidepressants used in psychiatry and addiction

Use

Drug

diarrhea

dizziness

headache

insomnia

nausea

weight

2°AD 1 prevent nicotine addiction relapse

bupropion

1.2 - 16%

3.4 - 21.6%

18.4 - 36%

13.3 - 18.7%

8.9 - 20.6%

NR

2nd generation antidepressant (2°AD) & pap

citalopram

1.8 - 11.8%

NR

0 - 24.1%

1.6 - 11.2%

0 - 24.8%

NR

2°AD& pap & social phobia (sp)

escitalo

pram

1.6 - 16.1%

NR

0 - 29.9%

1.3 - 16.2%

6.1 - 23.5%

NR

2°AD & compulsive obsessive trouble (cot)

fluoxetine

6.8 - 16.6%

4.3 - 10.0%

10.2 - 23%

10 - 17.4%

15.1 - 22.1%

0 - 10.7%

2°AD & cot

fluvoxa

mine

NR

NR

0 - 41.5%

NR

0 - 46.8%

NR

2°AD

mirtaze

pine

0 - 22.4%

2.9 - 21.2%

6.3 - 17.9%

0 - 49.2

0 - 8.9%

10.5 - 16.4 %

2°AD & cot & sp & panic attack prevention (pap)

paroxe

tine

5.6 - 12.9%

4.6 - 10.4%

11.1 - 31.1%

8.6 - 20.1%

11.1 - 25.6%

1.1 - 18%

2°AD & cot

sertraline

10.2 - 20.6%

7.0 - 24.4%

12.8 - 27.6%

8.7 - 21.3%

14.4 - 24.6%

0 - 18.5 %

2°AD & anxiety & sp

venlafa

xine

1.0 - 10.1%

7 - 24.4%

8 - 17.6%

3.4 - 19 %

27.4 - 34 %

NR

Strengths and Limitations of SSRIs/SNRIs and Benzodiazepines for Use in Anxiety Disorders

Medication

Limitations

Strengths

Discontinuation Symptoms

SSRIs/

SNRIs

Slow onset, breakthrough and/or recurrent anxiety symptoms, induction of agitation/anxiety, sleep disturbance, sexual dysfunction, weight gain, cost

Approved for a variety of anxiety disorders, as well as depression. Treat comorbid depression, associated with minimal cardiovascular risk (SSRIs only)

Increased anxiety, irritability, insomnia,

increased depression, lethargy, dizziness, headache, paresthesias,

diaphoresis, tremor, nausea

Benzo

diaze

pines

Generally not recommended for long-term use, minimal impact on depressive symptoms, may exacerbate depression, psychomotor/cognitive impairment, effective versus somatic symptoms, abuse potential, ataxia and falls, respiratory depression

Rapid onset, Relatively low cost, High patient acceptance, Manage acute exacerbations of anxiety symptoms

Increased anxiety, irritability, insomnia,

increased depression, lethargy, dizziness, heightened sensations,

diaphoresis, tremor, seizures

Possible side effects of Non-Steroidal Anti-Inflammatory Drugs: Analgesics

Get emergency help if

Serious side effects include

Other side effects include

Stop your NSAID medicine and call

shortness of breath or trouble breathing

chest pain, weak-ness in one part or side of your body , slurred speech, swelling of the face or throat

heart attack, stroke, high blood pressure

heart failure from body swelling (fluid retention), kidney problems including, kidney failure, bleeding and ulcers in the stomach and intestine, low red blood cells (anemia), life-threatening skin reactions, life-threatening allergic reactions, liver problems including liver failure, asthma attacks in people who have asthma

stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, dizziness

nausea, more tired or weaker than usual, itching, your skin or eyes look yellow, stomach pain, flu-like symptoms,vomit blood, there is blood in your bowel movement or it is black and sticky like tar, unusual weight gain, skin rash or blisters with fever, swelling of the arms and legs, hands and feet