INTERACTIONS BETWEEN MEDICATION AND ALCOHOL/ILLICIT DRUGS |
|
Alcohol |
Amphetamine |
Cannabis |
Ecstasy |
Heroin |
Cocaine |
LSD |
Benzodiazepines |
Solvents |
ACE inhibitors |
3 |
|
|
|
|
|
|
|
|
Acetazolamide |
|
1 |
|
|
|
|
|
|
|
Adrenaline |
|
|
|
|
|
|
|
|
1 |
Alcohol |
|
|
1 |
|
1 |
1 |
|
1,3 |
|
Amitriptyline |
|
|
|
|
1;8 |
|
|
|
|
Ammonium chloride |
|
2 |
|
|
|
|
|
|
|
Amphetamine |
2 |
|
|
|
|
|
|
|
|
Antihypertensives |
|
|
|
|
|
|
|
3 |
|
Antipsychotics |
|
|
|
|
|
|
|
1 |
|
Aspirin |
|
|
|
|
8 |
|
|
|
|
Atropine |
9 |
|
|
|
|
|
|
|
|
Baclofen |
1 |
|
|
|
|
|
|
1 |
|
Barbiturates |
1 |
|
|
|
|
|
|
|
|
Bromocriptine |
3 |
|
|
|
|
|
|
|
|
Caffeine |
|
|
|
|
|
|
|
|
|
Calcium carbimide |
3 |
|
|
|
|
|
|
|
|
Carbamazepine |
3 |
|
|
|
|
|
2 |
|
|
Cannabis |
1 |
|
|
|
|
|
|
|
|
Cefamandole |
5 |
|
|
|
|
|
|
|
|
Cefoperazone |
5 |
|
|
|
|
|
|
|
|
Cefmenoxime |
5 |
|
|
|
|
|
|
|
|
Cefonicid |
5 |
|
|
|
|
|
|
|
|
Cefotetan |
5 |
|
|
|
|
|
|
|
|
Chloral hydrate |
1,3,5 |
|
|
|
1 |
|
|
1 |
|
Chlorpheniramine |
1 |
2 |
|
|
|
|
|
1 |
|
Chlorpromazine |
1 |
4 |
4 |
|
1,8 |
|
|
1 |
|
Chlorpropamide |
14 |
|
|
|
|
|
|
|
|
Cimetidine |
|
|
|
|
|
|
|
1 |
|
Cisapride |
1 |
|
|
|
|
|
|
1 |
|
Clomipramine |
|
|
|
|
1 |
|
|
|
|
Cranberry Juice |
|
2 |
|
|
|
|
|
|
|
Cycloserine |
13 |
|
|
|
|
|
|
|
|
Desipramine |
|
|
|
|
1 |
|
|
|
|
Disulfiram |
5 |
|
6 |
|
|
|
|
1 |
|
Doxepin |
|
|
|
|
8 |
|
|
|
|
Felodipine |
3 |
|
|
|
|
|
|
|
|
Fluoxetine |
|
|
6 |
|
|
|
1 |
1 |
|
Fluvoxamine |
|
|
|
|
|
|
|
1 |
|
Fluphenazine |
|
|
4 |
|
|
|
|
|
|
Glycopyrrolate |
9 |
|
|
|
|
|
|
|
|
Haloperidol |
|
|
|
|
8 |
|
|
|
|
Hyoscine |
1 |
|
|
|
|
|
|
|
|
Indomethacin |
|
|
|
|
8 |
7 |
|
|
|
Isoniazid |
|
|
|
|
|
|
|
1 |
|
Levodopa |
|
|
|
|
|
|
|
4 |
|
Lithium |
|
2 |
|
|
|
2 |
|
|
|
Lofexidine |
1 |
|
|
|
|
|
|
1 |
|
MAOIs |
|
3 |
|
|
|
3 |
|
|
|
Metformin |
15 |
|
|
|
|
|
|
|
|
Metronidazole |
5 |
|
|
|
|
|
|
|
|
Nabilone |
1 |
|
|
|
|
|
|
1 |
|
Naproxen |
|
|
|
|
8 |
|
|
|
|
Nifedipipine |
3 |
|
|
|
|
|
|
|
|
Nitrates |
3 |
|
|
|
|
|
|
|
|
Nitrefazole |
3 |
|
|
|
|
|
|
|
|
Omeprazole |
|
|
|
|
|
|
|
1 |
|
Opioid analgesics |
1,3 |
|
|
|
|
|
|
1,3 |
|
Oral contraceptives |
|
|
|
|
2 |
|
|
|
|
Paraldehyde |
1 |
|
|
|
|
|
|
|
|
Phenytoin |
|
|
|
|
8 |
|
|
|
|
Piroxicam |
|
|
|
|
|
|
|
|
|
Primadone |
1 |
|
|
|
|
|
|
|
|
Procarbazine |
5 |
|
|
|
|
|
|
|
|
Propranolol |
3 |
|
|
|
|
11 |
|
|
|
Rifampicin |
|
|
|
|
2 |
|
|
2 |
|
Ritonavir |
|
|
|
12 |
2 |
|
|
1 |
|
Secobarbital |
1 |
|
|
|
1 |
|
|
1 |
|
Sodium bicarbonate |
|
1 |
|
|
|
|
|
|
|
SSRIs |
1 |
|
|
12 |
|
|
|
|
|
Theophylline |
|
|
4 |
|
|
|
|
|
|
Thiethylperazine |
|
|
|
|
8 |
|
|
|
|
Tinidazole |
5 |
|
|
|
|
|
|
|
|
Tizanidine |
1 |
|
|
|
|
|
|
1 |
|
Tricyclic antidepressants |
1,3 |
|
10 |
|
|
|
|
|
|
Verapamil |
1,3 |
|
|
|
|
|
|
|
|
Warfarin |
3 |
|
|
|
|
|
|
|
|
1:Increased effect/toxicity of drug of abuse; 2: Reduced effect of the drug of abuse: 3: Increased effect/toxicity of prescribed medication; 4:Reduced efficacy of prescribed medication; 5: Disulfiram (Antabuse)-like reaction; 6: Maniac reaction; 7: Risk to unborn child; 8: Myoclonus; 9: Impaired attention – mechanism unknown; 10: Tachycardia; 11: Coronary vasoconstriction; 12: Serotinergic syndrome; 13: Seizures; 14: Flushing; 15: Lactic acidosis |
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